Club de Revistas de Dermatopatología. Mierc 25 de abril 2012.10:00 am
21.04.2012 18:02Cutaneous Clear Cell Neoplasms: A Histopathological Reappraisal
Asok Biswas, MD, FRCPath, DipRCPath* and Meera Mahalingam, MD, PhD, FRCPath†
Am J Dermatopathol 2012;34:237–254
Abstract: Cutaneous clear cell neoplasms represent a heterogenous group of several primary and metastatic tumors with diverse histogenesis. Tumors with widespread clear cell change can seem strikingly similar under the microscope resulting in diagnostic difficulties.
Although most cases are idiopathic, intracytoplasmic accumulation, artifact of tissue processing, and degenerative phenomenon have been cited as possible causes of clear cell change. An awareness of the various entities demonstrating this attribute, judicious use of ancillary techniques, and knowledge of the clinical setting are crucial to the
accurate diagnosis. This review details the histological features of clear cell neoplasms of the skin with particular emphasis on the discriminating features.
LEARNING OBJECTIVES
After completing this CME activity, physicians should better be able to:
1. Classify the wide spectrum of cutaneous neoplasms presenting with clear cell change.
2. Formulate a clinicopathological strategy to arrive at an accurate diagnosis.
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