Febrero 21 2011. Club de Revistas de Dermatopatologia

Histopathological Variants of Cutaneous Squamous Cell Carcinoma: A Review

Valerie R. Yanofsky,1 Stephen E.Mercer,2 and Robert G. Phelps2
Journal of Skin Cancer. Volume 2011, Article ID 210813, 13 pages

Free Download    www.ncbi.nlm.nih.gov/pmc/articles/PMC3018652/pdf/JSC2011-210813.pdf

While most SCC lesions are indolent tumors with low malignant potential, a wide diversity of SCC subtypes exist, several of which are associated withmarkedlymore aggressive behaviors. Distinguishing these high-risk variants from their counterparts is possible through microscopic analysis, since each subtype possesses unique histopathological features.

Histological differences between low-grade and high-grade SCC.
Low-Grade SCC
Well to moderately differentiated: intercellular bridges and keratin pearls. Tumor cells arranged in solid or sheet-like patterns. Association with solar damage and precursor actinic keratosis. Diameter less than 2 cm. Depth less than 2mm
High-Grade SCC
Poorly differentiated: clear-cell, sarcomatoid, or single cell features. Presence of infiltrating individual tumor cells. Arising de novo or in site of prior injury (ulcer, burn scar, or osteomyleitis). Perineural and/or perivascular invasion. Diameter greater than 2 cm. Depth greater than 2mm.

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