Human Intermediate Filament Database
The Human Intermediate Filament Database was initiated by the Human Genetics Unit, University of Dundee in 2001 and was revised by the Centre for Molecular Medicine and the Bioinformatics Institute in Singapore in 2006, from where it is now being curated (contact us).
Intermediate filaments are part of the cytoskeleton, the flexible scaffold of polymeric filaments in the cytoplasm that is essential for structural integrity of the cell. Intermediate filament proteins are encoded by a large multigene family with an estimated 70 genes in the human genome plus a small number of alternatively spliced transcripts. Six classes of intermediate filament have been described, the two largest of which are the keratins (type I and type II intermediate filaments).
